DMT
Global History, Pharmacology, and Modern Practice
The briefest, strangest door in the pharmacopoeia.
Prepublication edition v0.22 · EPUB · 346 sources
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About this volume
N,N-dimethyltryptamine occurs in dozens of plants and, possibly, in us. Indigenous South America knew it for centuries through snuffs and brews before Western chemistry isolated it. Smoked or vaporized, it produces the shortest and by many accounts the strangest experience in this series: minutes long, fully immersive, and famously hard to describe.
The volume covers the chemistry and the brain science, the landmark New Mexico studies that restarted human psychedelic research in the 1990s, the reports of encountered presences that have puzzled researchers since, and the new clinical work on extended-state infusions that is turning the briefest psychedelic into a controllable one.
Synthesized from 346 sources, including the peer-reviewed pharmacology and human-imaging literature, the clinical-trial record for vaporized DMT and the 2026 intravenous infusion trial in major depression, the ethnobotany of yopo and cebil, the archaeology of Andean and Amazonian ritual use, and the contemporary regulatory record.
Inside the book
- IOrigins · Chapters 1 to 3The substance and its first uses, the lineages that carried it, and the ethics of writing about it at all.
- IIMechanism · Chapters 4 to 6The molecule, receptors, and dose; the brain under the influence; what doesn’t mix.
- IIIExperience · Chapters 7 to 9The arc of an experience, what it is like inside, and when it turns difficult.
- IVMedicine · Chapters 10 and 11The clinical evidence, indication by indication, read closely and without inflation.
- VPractice · Chapters 12 to 15Ceremony, clinic, and solo practice; set and setting; harm reduction; integration.
- VILandscape · Chapters 16 and 17Legal status, the regulatory moment, and the questions still open.